PLUNA Líneas Aéreas Uruguayas S.A. was the flag carrier of Uruguay. It was headquartered in Carrasco, Montevideo and operated scheduled services within South America, as well as scheduled cargo and charter services from its hub at Carrasco International Airport.

On 5 July 2012, only two days after the carrier's employees went on strike amid mounting financial difficulties, the Uruguayan government decided to close the airline down and to liquidate it. The carrier was wholly owned by the government at the time of its closure.

The airline was established in September 1936 and started operations the following month, on 19 November 1936. It was set up by Jorge and Alberto Márquez Vaesa, two brothers who had obtained the necessary financial and technical support through the ambassador of the United Kingdom to Uruguay at the time, Sir Eugen Millington-Drake. The airline became a wholly government-owned company on 12 November 1951.

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