The Cape Fear River is a 202 miles (325 km) long blackwater river in east central North Carolina in the United States. It flows into the Atlantic Ocean near Cape Fear, from which it takes its name.

In October 1662, the English explorer William Hilton Jr. made a three-week reconnaissance of the lower reaches of the Cape Fear River. Hilton's report contained favorable comments on the fish, fowl, and wildlife of the region. He noted "vast meddows, besides upland fields," "greatt swamps laden with varieties of great oakes, and other trees of all sorts," and the potential for good growing conditions. Hilton wrote that the Indians were "very poor and silly Creatures," that he had observed fewer than one hundred of them, but that they were "very theevish." He wished "all Englishmen, that know how to improve and use a plentiful Countrey and condition, not to delay to posses it...."

During the colonial era, the river provided a principal transportation route to the interior of North Carolina. Today the river is navigable as far as Fayetteville through a series of locks and dams. The estuary of the river furnishes a segment of the route of the Intracoastal Waterway.

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