Port Pirie (post code: 5540) is the sixth most populous city in South Australia after Adelaide, Mount Gambier, Whyalla, Murray Bridge and Port Lincoln. It is a seaport on the east coast of the Spencer Gulf, 223 km (139 mi) north of Adelaide. At June 2015 Port Pirie had an estimated urban population of 14,247. In 1846, Port Pirie Creek was named by Governor Robe after the John Pirie, the first vessel to navigate the creek when transporting sheep from Bowman's Run near Crystal Brook. In 1848, Matthew Smith and Emanuel Solomon bought 85 acres (34 ha) and subdivided it as a township to be known as Port Pirie. Little development occurred on site and by the late 1860's there were only three woolsheds on the riverfront.

With the discovery of rich silver-, lead- and zinc-bearing ore at Broken Hill in 1883, and the completion of a narrow gauge railway from Port Pirie to close to the Broken Hill field in 1888, the economic activities of the town shifted. In 1889 a lead smelter was built by the British Blocks company to treat Broken Hill ore.

By 1921 the town's population had grown to 9801 living in 2308 occupied dwellings. Port Pirie was declared South Australia's first provincial city in 1953, and today it is South Australia's second largest port. It is characterized by a gracious main street and some interesting and unusual historic buildings.

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