Near the end of his professional career (as a screenwriter, director, and actor), John Huston (1906 - 1987) began to act in the film industry. In 1963, director Otto Preminger asked if he would portray a Boston prelate in The Cardinal (1963). Author Philip Kemp wrote that he (Huston) "virtually stole the picture." He was nominated for an Academy Award for Best Supporting Actor for his role in the film. He did not win the Oscar. And he has never been nominated for a Best Actor Academy Award.

Years later, after The Cardinal in Roman Polanski's Chinatown (1974), Huston acted as the film's master villain. Huston said he did not regard himself very highly as an actor. But he said, "I do like and I'm very proud of my performance in the movie Chinatown. Also, he pointed out that he greatly enjoyed acting in Winter Kills.

John Huston won the Academy Award for Directing and Academy Award for Writing Adapted Screenplay in 1948 for his work on The Treasure of the Sierra Madre. Walter Huston, John Huston's father, also won the Academy Award for Best Supporting Actor for his role in this film, the first father-son win. The film was also nominated for the Best Picture award; but it lost to Laurence Olivier's film adaptation of Hamlet.

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