Sharpsburg, Maryland was the closest town to the battle. However, the actual battle took place on both sides of a small creek which ran just outside of Sharpsburg - Antietam Creek.

The battle took place on September 17, 1862. This became the bloodiest day in American military history. The number of casualties was shocking: 22,717 Union and Confederate soldiers were killed, wounded or reported as missing.

Although there was no clear "winner" of this battle, it proved to be a great tactical victory for the forces of the Northern states; the Southern forces were halted after a string of stunning victories under their commander, Robert E. Lee, and were forced to retreat from Maryland and return to Virginia.

More Info: en.wikipedia.org