Catherine Tramell is a fictional character and main antagonist in the film Basic Instinct (1992) and its sequel, Basic Instinct 2 (2006). Catherine, created by writer Joe Eszterhas, is played by Sharon Stone in both films. In Basic Instinct, Tramell is a serial killer and love interest of washed-up detective Nick Curran; Basic Instinct 2 pairs her with the similarly troubled British psychologist Michael Glass.

One European critic defined Catherine Tramell as "a mix between the classic femme fatale and the new psycho killers, one of the most evil characters ever created, on Hannibal Lecter's level". She was nominated to be a member of the American Film Institute's "Best Villains" list. She was also included as one of the best 250 fiction villains ever created. In June 2010, Entertainment Weekly named her one of the 100 Greatest Characters of the Last 20 Years.

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