First introduced in 1876, Heinz Tomato Ketchup remains the best selling brand of ketchup. From 1906 it was produced without preservatives. In 1907, Heinz started producing 13 million bottles of ketchup per year, exporting ketchup all over the world, including India, Australia, South America, Japan, Indonesia, New Zealand, South Africa and the United Kingdom. Heinz ketchup is often served at restaurants in the United States and Canada, as well as many other countries. As a condiment for many foods, such as french fries, chips, hamburgers and hot dogs, Heinz ketchup uses the slogan, "America's Favorite Ketchup." As of 2012, there are more than 650 million bottles of Heinz Tomato Ketchup being sold every year throughout the world.

In January 2009, the label design was altered, with the illustration of a gherkin pickle that had adorned the label since the 1890's removed and replaced with an illustration of a vine-ripened tomato accompanied by the slogan "Grown not made".

In addition to the standard ketchup variety, Heinz offers two varieties known as "Organic" and "Simply Heinz". Both of these varieties' ingredients contain sugar instead of high fructose corn syrup. Heinz offers several flavor variations: sriracha, jalapeño, and balsamic vinegar. Dietary requirements are addressed with no-salt-added and reduced-sugar varieties.

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