Tabasco sauce is a brand of hot sauce made exclusively from tabasco peppers (Capsicum frutescens var. tabasco), vinegar, and salt. It is produced by McIlhenny Company of Avery Island, Louisiana.

Although the name comes from the Mexican state of Tabasco, the sauce is an American product produced by McIlhenny Company.

Tabasco sauce was first produced in 1868 by Edmund McIlhenny, a Maryland-born former banker who moved to Louisiana around 1840. McIlhenny initially used discarded cologne bottles to distribute his sauce to family and friends. In 1868 when he started to sell to the public he ordered thousands of new cologne bottles from a New Orleans glass supplier. On his death in 1890, McIlhenny was succeeded by his eldest son, John Avery McIlhenny, who expanded and modernized the business, but resigned after only a few years in order to join Theodore Roosevelt's 1st US Volunteer Cavalry Regiment, the Rough Riders.

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