The Plug Uglies were an Irish American street gang, sometimes referred to as a political club, that operated in the west side of Baltimore, Maryland from 1854 to 1865 and later, in the Five Points, of New York City.

The Plug Uglies coalesced shortly after the creation of the Mount Vernon Hook-and-Ladder Company, a volunteer fire company whose truck house was on Biddle Street, between Pennsylvania Avenue and Ross Street (later Druid Hill). They were originally runners and rowdies affiliated with Mount Vernon.The gang associated with the emerging American Party also, known as the Know Nothings, in Baltimore.

Like similar associations in Baltimore and other United States cities during this period, the Plug Uglies' street influence made them useful to party politicians anxious to control the polls on Election Days. The Plug Uglies were the central figures in the first election riot in Baltimore in October 1855. Together with the Rip Raps, they were also actively involved in deadly rioting at the October 1856 municipal election in Baltimore and in similar violence at the Know-Nothing Riot in Washington in June 1857.

The gang was featured in Herbert Asbury's book Gangs of New York, and Luc Sante's chronicle of old New York, Low Life.

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