Amy Hughes is a British marathon runner who holds the Guinness World record of completing 53 marathons in 53 consecutive days. Hughes decided that she wanted to break the previous marathon running record in order to raise money for the Isabelle Lottie Foundation, which "raises awareness about the importance of diagnosing brain tumors early in children". She was also inspired by Larry Macon, who ran across all 50 U.S. states, desiring to run in all the major cities of the United Kingdom. Hughes also wanted to promote "the importance of leading a healthy, active lifestyle".

She started her first run on August 6, 2014, in Chester, England. From Chester, she travelled from north to south and then to the south-west, before travelling north and completing her 53rd marathon in Manchester on September 27, 2014. With each marathon 26 miles and 385 yards long, she ran just over 1389 miles. Hughes travelled to cities including London, Liverpool, Wolverhampton, Newcastle, Glasgow, and Cardiff. After the event, Hughes said her highlight was Brighton, and that Tunbridge Wells was "hilly". During the attempt, Hughes suffered from stomach viruses, one of which caused her to take 8 hours to run her 35th marathon around Taunton. She went through five pairs of trainers during the 53 days. The previous record for the most marathons run on consecutive days was 17 for women and 52 for men.

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