The Cleveland Lou Ruvo Center for Brain Health was designed by Frank Gehry, a Canadian-born American architect, residing in Los Angeles. His style is known as deconstructivism, a Postmodern architectural style characterized by the idea of fragmentation and the manipulation of a structure's surface.

Some of Gehry's best-known works are Guggenheim Museum in Bilbao, Spain; Walt Disney Concert Hall in downtown Los Angeles; Louis Vuitton Foundation in Paris, France; Dancing House in Prague; the Cinémathèque Française in Paris.

The construction of the Lou Ruvo Centre was started on February 9, 2007. The Centre was opened for Patient Care on July 13, 2009. On May 21, 2010, the building was completed.

The Center was built and supported by Keep Memory Alive (KMA) founded by Larry Ruvo, senior managing partner of Southern Wines and Spirits, in memory of his father, Lou Ruvo, a victim of Alzheimer's Disease. Its mission is to treat patients with such brain disorders as Alzheimer’s, Huntington’s, Parkinson’s, and Multiple Sclerosis. Since its inception in 1995, the foundation has raised over $235 million and treated over 23,000 patients.

The Center is approximately 65,000 sq ft (6,000 m2) and includes examination rooms, offices for healthcare practitioners, a “Museum of the Mind,” and a community auditorium. The Center also serves as the headquarters for KMA Foundation, the Las Vegas Alzheimer's Association, and the Las Vegas Parkinson's Disease Association.

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