The Girl from U.N.C.L.E. stars Stefanie Powers as American U.N.C.L.E. agent April Dancer and Noel Harrison (son of Rex Harrison) as her British partner, Mark Slate. Leo G. Carroll plays their superior, Alexander Waverly. The character name "April Dancer" was suggested by James Bond creator Ian Fleming who was a consultant in the creation of the parent program shortly before his death.

The series was not as successful as its parent program and was cancelled after 29 episodes due to low ratings. Several crossover episodes were produced in conjunction with The Man from U.N.C.L.E., including the episode that introduced April and Mark. In their first appearance they were portrayed by Mary Ann Mobley and Norman Fell, respectively.

In the memorable Girl crossover episode "The Mother Muffin Affair", Napoleon Solo (Robert Vaughn) teamed up with April Dancer. with Boris Karloff dressed in drag as the titular villainess Mother Muffin.

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