Stuart Little is a 1999 American live-action/computer animated family film directed by Rob Minkoff. It is loosely based on the novel of the same name by E. B. White. It combines live action and computer animation. The screenplay was written by M. Night Shyamalan and Greg Brooker. The plot bears little resemblance to that of the book, as only some of the characters and one or two minor plot elements are the same. The film's sequel more closely resembles the original novel.

In this, Minkoff's first live-action film, Michael J. Fox is the voice of Stuart Little. Geena Davis and Hugh Laurie star as Eleanor and Frederick Little, with Jonathan Lipnicki as Stuart's big brother George and Nathan Lane as the voice of the family cat Snowbell.

The film was released on December 17, 1999, by Columbia Pictures. It received an Academy Award for Best Visual Effects nomination, but lost to The Matrix. The film, the first in the film series, spawned a sequel in 2002, Stuart Little 2, the short-lived television series Stuart Little: The Animated Series in 2003, and another sequel in 2005, the direct-to-video Stuart Little 3: Call of the Wild.

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