During his fifth year as vice president, Spiro Agnew was under investigation by the United States Attorney's office in Baltimore, Maryland, on charges of extortion, tax fraud, bribery and conspiracy. Agnew was formally charged with having accepted bribes totaling more than $100,000 while holding office as Baltimore County Executive, Governor of Maryland, and Vice President of the United States.

On October 10, 1973, Agnew was allowed to plead no contest to a single charge that he had failed to report $29,500 of income received in 1967, with the condition that he resign the office of Vice President. Agnew is the only Vice President in U.S. history to resign because of criminal charges.

Spiro Agnew specifically served as the 39th Vice President of the United States from 1969 to 1973, under President Richard Nixon. The entire situation with Agnew's resignation is in fact ironic because of the timing. Agnew resigned less than a year before Richard M. Nixon's resignation as president of the United States. Spiro Agnew could have become the U.S. president if he had not been required to resign in disgrace.

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