Newman's last movie appearance was as a conflicted mob boss in the 2002 film Road to Perdition, opposite Tom Hanks, for which he was nominated for an Academy Award for Best Supporting Actor.

Road to Perdition is a 2002 American crime film directed by Sam Mendes. The screenplay was adapted by David Self from the graphic novel of the same name by Max Allan Collins. The film stars Tom Hanks, Paul Newman, Jude Law, and Daniel Craig. The plot takes place in 1931, during the Great Depression, following a mob enforcer and his son as they seek vengeance against a mobster who murdered the rest of their family.

Filming took place in the Chicago area. Mendes, having recently finished 1999's acclaimed American Beauty, pursued a story that had minimal dialogue and conveyed emotion in the imagery. Cinematographer Conrad L. Hall took advantage of the environment to create symbolism for the film, for which he won several awards, including a posthumous Academy Award for Best Cinematography. The film explores several themes, including the consequence of violence and father-son relationships.

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