The Grand Canal is a channel in Venice, Italy. It forms one of the major water-traffic corridors in the city.

One end of the canal leads into the lagoon near the Santa Lucia railway station and the other end leads into the basin at San Marco; in between, it makes a large reverse-S shape through the central districts (sestieri) of Venice. It is 3.8 km (2.4 mi) long, and 30 to 90 m (98 to 295 ft) wide, with an average depth of 5 metres (16 feet).

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