The Virginia opossum, commonly known as the North American opossum, is the only opossum found north of Mexico, with its range additionally extending south into Central America. Its range makes it both the northernmost opossum and the northernmost marsupial in the world. In the United States, the animal is typically referred to simply as a possum or an opossum. It is a solitary and nocturnal animal about the size of a domestic cat, and a successful opportunist.

The Virginia opossum has a lower internal body temperature than the rabies virus prefers and therefore is resistant but not immune to rabies. Rabies is a viral disease that causes inflammation of the brain in humans and other mammals.

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