Lake Amadeus is a large salt lake in the southwest corner of Northern Territory of Australia, about 50 kilometres (31 mi) north of Uluru (Ayers Rock). The smaller Lake Neale is adjacent to the northwest.

Due to the aridity of the area, the surface of Lake Amadeus is usually a dry salt crust. In times of sufficient rainfall, it is part of an east-flowing drainage system that eventually connects to the Finke River. Lake Amadeus is 180 kilometres (110 mi) long and 10 kilometres (6.2 mi) wide, making it the largest salt lake in the Northern Territory.

The first European to discover the lake, the explorer Ernest Giles, encountered it in 1872. Giles originally intended to honour his benefactor Baron Ferdinand von Mueller with the eponym Lake Ferdinand. However, Mueller prevailed upon Giles to instead honour King Amadeo I of Spain (reigned 1870-1873, known in English as King Amadeus I), who had previously bestowed honour on him.

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