The Great Sandy Desert (GSD) is an interim Australian bioregion, located in the north west of Western Australia straddling the Pilbara and southern Kimberley regions. It is the second largest desert in Australia after the Great Victoria Desert and encompasses an area of 284,993 square kilometres (110,036 sq mi). The Gibson Desert lies to the south and the Tanami Desert lies to the east of the Great Sandy Desert.

The Great Sandy Desert contains large ergs, often consisting of longitudinal dunes. In the north east of the desert there is a meteorite impact crater, the Wolfe Creek crater.

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