From the U.S. drama series listed above, "Crime Story" (1986 - 1988) is the TV series which did not include Mark Harmon in a recurring starring role. With this series, it concerns crime in 1960s Chicago, IL. Lieutenant Mike Torello and the members of his Major Crime Unit carry on a near-epic battle against organized crime figures such as Ray Luca. "Crime Story" has a serialized format, in which a continuing storyline is told over an entire season. This crime series was created by Chuck Adamson and Gustave Reininger and aired on the NBC Network. The show's major star is Dennis Farina as Mike Torello. Mark Harmon totally starred on other TV shows during 1986 - 1988.

On "St. Elsewhere" (1982 - 1988), Mark Harmon held a recurring role as Dr. Robert Caldwell (1983–1986).

In 1980, Harmon gained a regular role in the prime time soap opera "Flamingo Road" (1980 - 1982), in which he played Fielding Carlisle, the husband of Morgan Fairchild's character.

Since September 2003, Mark Harmon has starred as NCIS agent Leroy Jethro Gibbs on the CBS drama "NCIS". This is a series which has a true focus on how the United States Department of the Navy, which includes the United States Marine Corps, primary conducts law enforcement and counterintelligence activities for the USA. The seventeenth season of "NCIS" premiered in September 2019.

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