Ethel Barrymore was born Ethel Mae Blythe in Philadelphia, the second child of the actors Maurice Barrymore (whose real name was Herbert Blythe) and Georgiana Drew. She was named for her father’s favorite character—Ethel in William Makepeace Thackeray’s The Newcomes.

She was the sister of actors John Barrymore and Lionel Barrymore, the aunt of actor John Drew Barrymore, and the grand-aunt of actress Drew Barrymore. She was also a granddaughter of actress and theater-manager Louisa Lane Drew, and niece of Broadway matinée idol John Drew Jr and early Vitagraph Studios movie star Sidney Drew.

She spent her childhood in Philadelphia, and attended Roman Catholic schools there.

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