The Indianapolis 500-Mile Race (better known as the Indianapolis 500) is an automobile race held annually at Indianapolis Motor Speedway (IMS) in Speedway, Indiana, United States, an enclave suburb of Indianapolis, Indiana. The event is held on the last Sunday in May and over Memorial Day weekend in late May. It is contested as part of the Verizon INDYCAR Series, the top level of American Championship Car racing, an open-wheel open-cockpit formula colloquially known as "Indy Car Racing". The name of the race is often shortened to Indy 500, and the track itself is nicknamed "the Brickyard", as the racing surfacing was paved in brick in the fall of 1909.

Pete DePaolo pulled out to a huge lead in the 1925 Indianapolis 500. His strategy in the race was to run the left side tires in the oil slick on the middle the track for two laps then run his right side tires in the oil slick for two laps. His fingers became badly blistered around the midpoint of the race, and car owner Fred Duesenberg pulled DePaolo out of the car in favor of Norm Batten. DePaolo had his hands repaired in the infield care center, and returned in the car after missing 21 laps. He had dropped to fifth. He raced his way to the win on his way to the series drivers championship.

Pete did not consider this to be his greatest win (since he was replaced for 21 laps). Pete became the first driver to average more than 100 mph at the Indianapolis 500, recording 101.13 in his Duesenberg, 1925.

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