From 399 to 167 BC, Pella was the capital of Macedonia, an ancient kingdom on the northern periphery of Classical Greece. It was ruled during most of its existence initially by the founding dynasty of the Argeads, the intermittent Antipatrids and finally the Antigonids. Home to the Macedonians, the earliest kingdom was centered on the northeastern part of the Greek peninsula, bordered by Epirus to the west, Paeonia to the north, the region of Thrace to the east and Thessaly to the south.mnPrior to the fourth century BC, Macedonia was a small kingdom in northern Greece, outside the area dominated by the great city-states of Athens, Sparta and Thebes, and at one time was subordinate to Achaemenid Persia.

The reign of Philip II (359–336 BC) saw the rise of Macedonia, when the kingdom rose to control the entire Greek world. With the innovative Macedonian army, Philip defeated the old powers of Athens and Thebes in the decisive Battle of Chaeronea in 338 BC and subdued them, while keeping Sparta in check. His son Alexander the Great, born in Pella, pursued his father's effort to command the whole of Greece through the federation of Greek states, a feat he finally accomplished after destroying a revolting Thebes. Alexander then led this force in a large campaign against the Achaemenid Empire, in retaliation for the invasion of Greece in the 5th century BC.

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