The Number of the Beast is a term in the Book of Revelation, of the New Testament, that is associated with the Beast of Revelation in chapter 13. In most manuscripts of the New Testament and in English translations of the Bible, the number of the beast is 666.

Some avoid the number 666 out of superstition. Irrational fear of the number is called hexakosioihexekontahexaphobia, though the word is mainly used humorously because of its length. This word is derived from Ancient Greek roots hexakósioi, "six hundred", hexékonta, "sixty", and héx, "six"; literally meaning "fear of six hundred sixty-six".

In 1989, Nancy and Ronald Reagan, when moving to their home in the Bel-Air section of Los Angeles after the 1988 election, had its address—666 St. Cloud Road—changed to 668 St. Cloud Road.

The phobia has been a motif in various horror films such as The Omen and its 2006 remake. The number of the beast also appears in other films such as Pulp Fiction, The Doom Generation, End of Days, Bedazzled and The Phantom of the Opera.

Some women have expressed concern about giving birth on June 6, 2006 (6/6/06).

In 2015, US Representative Joe Barton had the number of a legislative bill he had introduced changed from 666 to 702 because "the original bill number carried many different negative connotations", according to a spokesperson.

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