Hepatic stellate cells are liver-specific mesenchymal cells that play vital roles in liver physiology and fibrogenesis. They are located in the space of Disse and maintain close interactions with sinusoidal endothelial cells and hepatic epithelial cells. It is becoming increasingly clear that hepatic stellate cells have a profound impact on the differentiation, proliferation, and morphogenesis of other hepatic cell types during liver development and regeneration.

A liver transplant is an operation to remove a diseased or damaged liver and replace it with a healthy one.

It's usually recommended when the liver has been damaged to the point that it cannot perform its normal functions. This is known as liver failure or end-stage liver disease.

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