When Bill Clinton took office as president in January 1993, Hillary Rodham Clinton became the First Lady of the United States, and her press secretary reiterated that she would be using that form of her name. She was the first person as first lady to hold a postgraduate degree and to have her own professional career as a lawyer up to the time of entering the White House.

She was also the first to have an office in the West Wing of the White House in addition to the usual first lady offices in the East Wing. She was part of the innermost circle vetting appointments to the new administration and her choices filled at least eleven top-level positions and dozens more lower-level ones. After Eleanor Roosevelt, many people have stated that Hillary Clinton is regarded as the most openly empowered presidential wife in American history.

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