Yes, there were five. They are Maria Teresa de Filippis during the years 1958-1959 from team Maserati, Behra-Porsche.

Divina Galica in 1976 racing for team Surtees, Hesketh.

Lella Lombardi during years1974-1976 from team March, Williams, Brabham.

Desiré Wilson in 1980 racing with team Williams.

Giovanna Amati in 1992 from team Brabham.

Of all of them, only Lombardi achieved 0.5 points in Spain in 1975 and only Desiré Wilson won a Formula 1 race of any kind.

More Info: es.wikipedia.org