The hand of benediction, also known as benediction sign or preacher's hand, occurs as a result of prolonged compression or injury of the median nerve at the forearm or elbow.

A benediction (Latin: bene, well + dicere, to speak) is a short invocation for divine help, blessing and guidance, usually at the end of worship service. However, the name is misleading as the patients with this median nerve problem usually can flex all fingers except for the index finger. The index finger is still extended at the metacarpophalangeal joint (MCP joint) when the ulnar nerve innervated muscles (the interossei muscles) are still working. The index finger is not flexed at the proximal interphalangeal (PIP) and distal interphalangeal (DIP) joints, which looks like a pointing finger. Pointing Finger is, therefore, a much better term to recognize this condition.

Median nerve originate from brachial nerve pluxeus in axilla from 8th and 1st thoracic nerve roots and ascending downwards to the anterior surface of elbow at cubital fossa and then downwards to the wrist at carpal tunnel and ends by supplying digital sensory nerves to median 3 and half fingers i.e thumb, index, middle and medial side of ring finger.

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