Bitter orange, Seville orange, sour orange, bigarade orange, or marmalade orange is the citrus tree "Citrus × aurantium" and its fruit. It is native to East Africa, the Arabian Peninsula, Syria, and Southeast Asia.

Wild trees are found near small streams in generally secluded and wooded parts of Florida and the Bahamas after it was introduced to the area from Spain, where it had been introduced and cultivated heavily beginning in the 10th century by the Moors.

Many varieties of bitter orange are used for their essential oil, and are found in perfume, used as a flavoring or as a solvent, and also for consumption. The Seville orange variety is used in the production of marmalade and also used to make French "bigarade".

Bitter orange is also employed in herbal medicine as a stimulant and appetite suppressant, due to its active ingredient, synephrine. Bitter orange supplements have been linked to a number of serious side effects and deaths, and consumer groups advocate that people avoid using the fruit medically.

While the raw pulp is not edible, bitter orange is widely used in cooking.

Bitter orange may have serious interactions with drugs such as statins in a similar way to the long list of grapefruit–drug interactions.

More Info: en.wikipedia.org