E = mc2. It's the world's most famous equation, but what does it really mean?
Energy equals mass times the speed of light squared." On the most basic level, the equation says that energy and mass (matter) are interchangeable; they are different forms of the same thing. Under the right conditions, energy can become mass, and vice versa. We humans don't see them that way—how can a beam of light and a walnut, say, be different forms of the same thing?—but Nature does.
Here's an example. If you could turn every one of the atoms in a paper clip into pure energy—leaving no mass whatsoever—the paper clip would yield 18 kilotons of TNT. That's roughly the size of the bomb that destroyed Hiroshima in 1945. On Earth, however, there is no practical way to convert a paper clip or any other object entirely to energy. It would require temperatures and pressures greater than those at the core of our sun.