Between 1492 and 1504, Italian explorer Christopher Columbus led four Spanish-based transatlantic maritime expeditions to the Americas, a continental landmass which was virtually unknown to and outside of the Old World (Afro-Eurasia). These voyages to America led to the widespread knowledge of its existence. This breakthrough inaugurated the period known as the Age of Discovery, which saw the colonization of the Americas, a related biological exchange, and trans-Atlantic trade. These events, the effects and consequences of which persist to the present, are sometimes cited as the beginning of the modern era.

Born in the Republic of Genoa, Columbus was a navigator who sailed for the Crown of Castile (a predecessor to the modern Kingdom of Spain) in search of a westward route to the Indies, thought to be the East Asian source of spices and other precious oriental goods obtainable only through arduous overland routes. Columbus was partly inspired by 13th-century Italian explorer Marco Polo in his ambition to explore Asia and never admitted his failure in this, incessantly claiming and pointing to supposed evidence that he had reached the East Indies. Ever since, the islands of the Caribbean have been referred to as the West Indies.

Christopher Columbus had three ships on his first voyage, the Santa Maria, the Santa Clara (nicknamed the Niña) and the Pinta.

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