221B Baker Street is the London address of the fictional detective Sherlock Holmes, created by author Sir Arthur Conan Doyle. In the United Kingdom, postal addresses with a number followed by a letter may indicate a separate address within a larger, often residential building. Baker Street in the late 19th century was a high-class residential district.

At the time the Holmes stories were published, addresses in Baker Street did not go as high as 221. Baker Street was later extended, and in 1932 the Abbey National Building Society moved into premises at 219–229 Baker Street. For many years, Abbey National employed a full-time secretary to answer mail addressed to Sherlock Holmes. In 1990, a blue plaque signifying 221B Baker Street was installed at the Sherlock Holmes Museum, situated elsewhere on the same block, and there followed a 15-year dispute between Abbey National and the Holmes Museum for the right to receive mail addressed to 221B Baker Street. Since the closure of Abbey House in 2005, ownership of the address by the Holmes Museum has not been challenged, despite its location between 237 and 241 Baker Street.

Mr Holmes shared his rooms with his loyal friend and colleague Dr Watson and the house is protected by the government due to its "special architectural and historical interest." The 1st-floor study overlooking Baker Street is faithfully maintained for posterity and just as it was kept by Mrs Hudson in Victorian Times!

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