The Yukon River is a major watercourse of northwestern North America. From its source in British Columbia, Canada, it flows through Canada's territory of Yukon (itself named after the river). The lower half of the river continues westwards through the U.S. state of Alaska. The river is 3,190 kilometres (1,980 mi) long and empties into the Bering Sea at the Yukon–Kuskokwim Delta.

The longest river in Alaska and Yukon, it was one of the principal means of transportation during the 1896–1903 Klondike Gold Rush. A portion of the river in Yukon—"The Thirty Mile" section, from Lake Laberge to the Teslin River—is a national heritage river and a unit of Klondike Gold Rush International Historical Park.

The Yukon River is home to one of the longest salmon runs in the world. Each year Chinook, coho, and chum salmon return to their terminal streams in Alaska, the Yukon Territory, and British Columbia. The villages along the Yukon have historically relied on and continue to rely on salmon for their cultural, subsistence, and commercial needs. Salmon are traditionally dried, smoked, and frozen for both human and sled-dog consumption.

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