The sacrum in human anatomy is a large, triangular bone at the base of the spine that forms by the fusing of sacral vertebrae S1–S5 between 18 and 30 years of age.

The sacrum is situated at the upper, back part of the pelvic cavity, between the two wings of the pelvis. It forms joints with four other bones.

In all other quadrupedal vertebrates, the pelvic vertebrae undergo a similar developmental process to form a sacrum in the adult, even while the bony tail (caudal) vertebrae remain unfused. The number of sacral vertebrae varies slightly. For instance, the S1–S5 vertebrae of a horse will fuse, the S1–S3 of a dog will fuse, and four pelvic vertebrae of a rat will fuse between the lumbar and the caudal vertebrae of its tail. The Stegosaurus dinosaur had a greatly enlarged neural canal in the sacrum, characterized as a "posterior braincase”.

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