Frances Wilson Grayson (c. 1892 – c. December 23, 1927) was an American woman who died flying to Newfoundland just prior to her attempt to cross the Atlantic Ocean. She was a niece of President Woodrow Wilson.

She met John Brady Grayson, and they married on September 15, 1914. They divorced with no children after nine years.

Frances Grayson then moved to Manhattan, New York City, where she was a writer for a newspaper. She then became a real estate agent.

While in Manhattan, Grayson became interested in aviation and in the idea of making a flight across the Atlantic Ocean. She bought a new Sikorsky S-36 amphibian plane, which she named Dawn, and received financing for the flight from Mrs. Aage Ancker. She recruited Royal Norwegian Navy Lieutenant Oskar Omdal to serve as the aircraft's pilot, Brice Goldsborough as its navigator, and Frank Koehler as its radio engineer. They made plans to begin the transatlantic flight from the Dominion of Newfoundland. Omdal was to fly the plane across the Atlantic, although Grayson may have planned to perform some of the flying herself.

The four took off from Curtiss Field on Long Island, New York, on the evening of December 23, 1927, bound for Harbor Grace in Newfoundland. They radioed that something was wrong later in the evening and never reached Newfoundland; their remains were never found. Their plane probably went down in the Atlantic off Nova Scotia during a storm. Grayson was 35 years old at the time of her death.

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