Known in all cultures, the toothpick is not just the oldest instrument for dental cleaning, but predates the arrival of early modern humans, for the skulls of Neanderthals, as well as Homo sapiens, show clear signs of teeth picked with a tool.

Toothpicks made of bronze have been found as burial objects in prehistoric graves in Northern Italy and in the East Alps. In 1986, researchers in Florida discovered the 7500-year-old remains of ancient Native Americans and discovered small grooves between many of the molar teeth.

There are delicate, artistic examples made of silver in antiquity, as well as from mastic wood with the Romans. In the 17th century, toothpicks were luxury objects and like jewelry, were artfully stylized using precious metal and set with expensive stones.

The first toothpick-manufacturing machine was developed in 1869, by Marc Signorello. Another was patented in 1872, by Silas Noble and J. P. Cooley.

Wooden toothpicks are cut from birch wood. Logs are first spiral cut into thin sheets, which are then cut, chopped, milled and bleached into the individual toothpicks.

Plastic toothpicks, also called dental pics, are still made in America in Georgia, by Armond's Manufacturing. The Mayo Clinic recommends using a dental pic in lieu of a wooden toothpick to clean one's teeth, as they clean more effectively and one does not risk injuring the gums. Nowadays other means of dental hygiene are preferred such as dental floss and toothbrushes.

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