Popeye's 4 nephews were quadruplets. They first appeared on the Fleisher Studios’ style sheets in 1939 when the feature films were still being released under the posthumous sanction of Segar. In an episode entitled “Wimmin is a Myskery,” Poopeye is replaced by Peepeye in a dream sequence featuring the four as Popeye’s children. Their first appearance as Popeye’s nephews occurs in a 1942 cartoon that names them. Their existence suggests Popeye had a sibling. Some cartoons such as “Big Bad Sindbad” and “Patriotic Popeye” feature only two or three of the nephews with no explanation as to the others’ absence. Popeye’s nephews also joined in the “All New Popeye Hour” where they often appear.

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