Mossel Bay (Afrikaans: Mosselbaai) is a harbour town of about 99,319 people on the Southern Cape (or Garden Route) of South Africa. Although it is today best known as the place at which the first Europeans landed on South African soil (Bartolomeu Dias and his crew arrived on 3 February 1488), Mossel Bay's human history can – as local archaeological deposits have revealed – be traced back more than 164,000 years.

The modern history of Mossel Bay began on 3 February 1488, when the Portuguese explorer Bartolomeu Dias landed with his men at a point close to the site of the modern-day Dias Museum Complex. Here they found a spring from which to replenish their water supplies. Dias had been appointed to search for a trading route to India by King John II of Portugal, and, without realising it, actually rounded the Cape of Good Hope before landing at Mossel Bay – which he named Angra dos Vaqueiros (The Bay of Cowherds).

By the time the Portuguese explorer Vasco da Gama reached the area in 1497, the Bay had been marked on the maps as Aguada de São Brás, (the Watering Place of St Blaize - whose feast is celebrated on 3 February). Da Gama bartered successfully for cattle with the local Khoi people in what is generally regarded as the first commercial transaction between Europeans and the indigenous people of South Africa.

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