Samarkand, alternatively Samarqand, is a city in south-eastern Uzbekistan and one of the oldest continuously inhabited cities in Central Asia. There is evidence of human activity in the area of the city from the late Paleolithic era, though there is no direct evidence of when Samarkand was founded; some theories propose that it was founded between the 8th and 7th centuries B.C. Prospering from its location on the Silk Road between China and the Mediterranean, at times Samarkand was one of the greatest cities of Central Asia.

By the time of the Achaemenid Empire of Persia, it was the capital of the Sogdian satrapy (a province governed by a satrap or governor). The city was taken by Alexander the Great in 329 B.C., when it was known by its Greek name of Marakanda.The city was ruled by a succession of Iranian and Turkic rulers until the Mongols under Genghis Khan conquered Samarkand in 1220. Today, Samarkand is the capital of Samarkand Region and Uzbekistan's second largest city.

The city is noted for being an Islamic centre for scholarly study. In the 14th century it became the capital of the empire of Timur (Tamerlane) and is the site of his mausoleum (the Gur-e Amir). The Bibi-Khanym Mosque, rebuilt during the Soviet era, remains one of the city's most notable landmarks. In 2001, U.N.E.S.C.O. added the city to its World Heritage List as Samarkand – Crossroads of Cultures.

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