Lod is an ancient city, and Neolithic remains have been discovered there. It is mentioned few times in the Hebrew Bible and in the New Testament. Between the 5th century BCE and up until the late Roman period, the city was a prominent center for Jewish scholarship and trade Around 200 CE, the city became a Roman colony and was renamed Diospolis (Ancient Greek: Διόσπολις, lit. 'city of Zeus'). Christian tradition identifies Lod as the 4th century martyrdom site of Saint George; the Greek Orthodox Church of Saint George located in the city is believed to house his remains. Following the Arab conquest of the Levant, Lod served as the capital of Jund Filastin; however, a few decades later, the seat of power was transferred to Ramla, and Lod slipped in importance.Under Crusader rule, the city was a diocese of the Latin rite and it remains a titular see to this day.

Lod underwent a major change in its population in the mid-20th century.Exclusively Palestinian Arab in 1947,Lod was part of the area designated for an Arab state in the United Nations Partition Plan for Palestine; however in July 1948 the city was occupied by the Israel Defense Forces, and most of its Arab inhabitants were expelled in the 1948 Palestinian exodus from Lydda and Ramle, also known as the Lydda Death March. The city was largely resettled by Jewish immigrants, most of them from Arab countries.Today, Lod is one of Israel's mixed cities, with an Arab population of 30%.

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