The well liked 1991 film that has Wesley Snipes as a successful architect and his underachieving brother being Samuel L. Jackson is "Jungle Fever". The film is an American romantic drama that was written, produced, and directed by Spike Lee. The film stars Snipes and Jackson along with Annabella Sciorra, Lee, Ossie Davis, Ruby Dee, Lonette McKee, John Turturro, Frank Vincent, Halle Berry, Tim Robbins and Anthony Quinn. "Jungle Fever" explores the beginning and end of an extramarital interracial relationship against the urban backdrop of the streets of New York City in the early 1990s.

The victims of "Jungle Fever" are Snipes as Flipper, an affluent, married, successful architect, and Sciorra as Angie, a temporary office worker. He is African-American; she is Italian-American. She comes to work in his Manhattan office one day, their eyes meet, and the fever starts. Their halting, tentative conversations expand into working late, eating Chinese food from the take-out, and finally having sex.

"Jungle Fever" is Spike Lee's term for unhealthy sexual attraction between the races. It is used for relationships based on stereotypes. Too often, Lee said, "When blacks and whites go to bed with one another, they are motivated, not by love or affection, but by media-based myths about the sexual allure of the other race."

The film got many positive reviews from critics, with particular high praise for Samuel L. Jackson. Commercially the film's profit was about $30 million.

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