Spandau Prison was located in the borough of Spandau in western Berlin. It was constructed in 1876 and demolished in August 1987 after the death of its last prisoner, Rudolf Hess who had died from a suspected suicide aged 93, to prevent it from becoming a neo-Nazi shrine. The site was later rebuilt as a shopping centre for the British forces stationed in Germany. It initially served as a military detention center. From 1919 it was also used for civilian inmates, holding up to 600 inmates at that time.

In the aftermath of the Reichstag fire of 1933, opponents of Hitler, and journalists such as Egon Kisch and Carl von Ossietzky, were held there in so-called protective custody. Spandau Prison became a sort of predecessor of the Nazi concentration camps. While it was formally operated by the Prussian Ministry of Justice, the Gestapo tortured and abused its inmates, as Egon Erwin Kisch recalls in his memories of Spandau Prison. By the end of 1933 the first Nazi concentration camps had been erected (at Dachau, Osthofen, Oranienburg, Sonnenburg, Lichtenburg and the marshland camps around Esterwegen); all remaining prisoners who had been held in so-called protective custody in state prisons were transferred to these concentration camps.

After World War II the prison fell in the British Sector of what became West Berlin but it was operated by the Four-Power Authorities to house the Nazi war criminals sentenced to imprisonment at the Nuremberg Trials.

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