Human decontamination is the process of removing hazardous materials from the human body, including chemicals, radioactive substances, and infectious material.

Persons suspected of being contaminated are usually separated by sex, and led into a decontamination tent, trailer, or pod, where they shed their potentially contaminated clothes in a strip-down room. Then they enter a wash-down room where they are showered. Finally they enter a drying and re-robing room to be issued clean clothing, or a jumpsuit or the like. Some more structured facilities include six rooms.

Some facilities, such as Modecs, and many others, are remotely operable, and function like "human car washes". Common lathering in soap, removes external dust that may contain radioisotopes. It is advised that when lathering, effort should be made not to spread potential dust that deposited onto exposed, unclothed areas of skin, to areas that were once likely clean.

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