Galileo was an American uncrewed spacecraft that studied the planet Jupiter and its moons, as well as several other Solar System bodies. Named after the Italian astronomer Galileo Galilei, it consisted of an orbiter and an entry probe. It was delivered into Earth orbit on October 18, 1989 by Space Shuttle Atlantis. Galileo arrived at Jupiter on December 7, 1995, after gravitational assist flybys of Venus and Earth, and became the first spacecraft to orbit Jupiter. It launched the first probe into Jupiter, directly measuring its atmosphere. Despite suffering major antenna problems, Galileo achieved the first asteroid flyby, of 951 Gaspra, and discovered the first asteroid moon, Dactyl, around 243 Ida. In 1994, Galileo observed Comet Shoemaker–Levy 9's collision with Jupiter.

Jupiter's atmospheric composition and ammonia clouds were recorded, the clouds possibly created by outflows from the lower depths of the atmosphere. Io's volcanism and plasma interactions with Jupiter's atmosphere were also recorded. The data Galileo collected supported the theory of a liquid ocean under the icy surface of Europa, and there were indications of similar liquid-saltwater layers under the surfaces of Ganymede and Callisto. Ganymede was shown to possess a magnetic field and the spacecraft found new evidence for exospheres around Europa, Ganymede, and Callisto. Galileo discovered that Jupiter's ring system consists of dust from impacts on the four small inner moons.

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