The first form of artificial refrigeration was invented by William Cullen, a Scottish scientist. Cullen showed how the rapid heating of liquid to a gas can result in cooling. This is the principle behind refrigeration that still remains today.

He was President of the Royal College of Physicians and Surgeons of Glasgow (1746–47), President of the Royal College of Physicians of Edinburgh (1773–1775) and First Physician to the King in Scotland (1773–1790). He also assisted in obtaining a royal charter for the Philosophical Society of Edinburgh, resulting in the formation of the Royal Society of Edinburgh in 1783.

Cullen was a beloved teacher, and many of his students became influential figures. He kept in contact with many of his students, including Benjamin Rush, a central figure in the founding of the United States of America; John Morgan, who founded the first medical school in the American colonies, the Medical School at the College of Philadelphia; William Withering, the discoverer of digitalis; Sir Gilbert Blane, medical reformer of the Royal Navy; and John Coakley Lettsom, the philanthropist and founder of the Medical Society of London

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