Who is the only pitcher since 1893 to throw a no-hitter in his first start in Major League Baseball?

Here the answer is the St. Louis Browns' big right-hander 'Bobo' Holloman. He is the only pitcher after 1893 to throw a no-hitter in his first start in Major League Baseball (MLB). He did this against the Philadelphia Athletics in May 1953. Alva Lee (aka "Bobo") Holloman was a pitcher in Major League Baseball who only played for one season in the American League with the St. Louis Browns in 1953. He would play in just 22 games during his career. As a pitcher, Holloman pitched 65.1 innings and posted a win-loss record of 3–7 and a 5.23 earned run average.

At the age of 27 years, Holloman struck out three, walked five, and helped himself offensively by batting in three of the Browns’ runs with a pair of singles in the Browns’ 6-0 no-hitter victory over the Athletics. At the time, St. Louis Browns’ owner Bill Veeck, viewed as a great innovator in the history of baseball, sent $10,000 and pitcher Duke Markell to the Syracuse Chiefs in exchange for the services of Bobo Holloman.

After his first start, Bobo could never achieve the same type of success. He ended his MLB career with a solid losing record as a pitcher.