Clifford Etienne (born March 9, 1970) is an American former professional boxer who is currently serving a 105-year prison sentence without possibility of parole. Known for his aggressive, high-volume style despite being a heavyweight, he fought the likes of Mike Tyson, Francois Botha, Nikolay Valuev, Calvin Brock, and Lamon Brewster.

Etienne landed a contract with Showtime and his stock began to rise, but it quickly fell after an upset loss to Fres Oquendo, who stopped Etienne in the eighth round of their fight in March 2001. After re-building some of his lost stature with wins, he was catapulted to the world's stage in a 2003 fight against Mike Tyson, where Etienne suffered a first-round knock-out only 49 seconds after being caught with a short right hand from Tyson.

The pre-fight was marred by rumors of Tyson's lack of fitness. Some said that he took time out from training to party in Las Vegas and get a new facial tattoo. This eventually proved to be Tyson's final professional victory in the ring.

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