Pope Clement VII was pope when Emperor Charles V invaded Italy and sacked Rome. Clement VII served as Pope from 1523 to 1534. He was a member of the powerful Medici family, and he possessed great political and diplomatic skills. But, he lacked the understanding of the age and was not able to cope with the political and religious changes he faced. His relationship with Emperor Charles V was very bad in May 1527.

After Rome was sacked, Clement VII was Imprisoned. He was forced into a humiliating compromise which caused him to give up a great deal of secular and religious power. Eventually, Clement VII became ill and never recovered. He died on September 25, 1534, hated by the people of Rome, who never forgave him for the destruction of Rome.

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