Of the seven war criminals held at Spandau Prison, three were released after serving their full sentences, while three others (including Raeder and Funk, who were given life sentences) were released earlier due to ill health. Between 1966 and 1987, Rudolf Hess was the only inmate in the prison and his only companion was the warden, Eugene K. Bird, who became a close friend. Bird wrote a book about Hess's imprisonment titled The Loneliest Man in the World.

The prison was demolished in 1987, largely to prevent it from becoming a Neo-Nazi shrine, after the death of its final remaining prisoner, Rudolf Hess, who had been the prison's sole occupant after the release of Speer and von Schirach in 1966. To further ensure its erasure, the site was made into a parking facility and a NAAFI shopping center, named The Britannia Centre Spandau and nicknamed Hessco's after the well known British supermarket chain, Tesco's. All materials from the demolished prison were ground to powder and dispersed in the North Sea or buried at the former RAF Gatow airbase. In 2013 a single brick turned up on the BBC program Antiques Roadshow.

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