"Do Do Do Down dooby doo down down, comma, comma" are the lyrics that start off which 1960s American #1 song?

"Breaking Up Is Hard to Do" is a song recorded by Neil Sedaka. Sedaka recorded this song twice, in 1962 and 1975, in two significantly different arrangements. Sedaka once recalled that the song's iconic scat intro " Do Do Do Down Dooby Do Down Down", was a result of being unable to come up with a lyric for that section of the song and improvising a vocal line. He liked it so much that it was left in the finished product.

"Breaking Up Is Hard to Do", hit number one on the "Billboard Hot 100" on August 11, 1962. The single was a solid hit all over the world, reaching number 7 in the UK. In various countries it was translated into appropriate languages. For example, the Italian version was called "Tu non lo sai" ("You Don't Know") and was recorded by Sedaka himself. Thirteen years later, after several years in career decline, Sedaka, in the midst of a comeback in his native United States, re-recorded this song in a slower style. Sedaka's slow version peaked at #8 in February 1976 and went to number one on the Easy Listening chart.

It is considered to be Sedaka's signature song.